{"metadata":{"accession":"G3TQ48","id":"G3TQ48_LOXAF","source_organism":{"taxId":"9785","scientificName":"Loxodonta africana","fullName":"Loxodonta africana (African elephant)"},"name":"Polycomb group RING finger protein 2","description":["Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity"],"length":343,"sequence":"MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGVREREEKKGPLENGDGDKEKQTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRLTLPTAPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATHPTSPTPPSTASGASTAANGGTSNCLQTPSSTSRGRKMTVNGAPVPP","proteome":"UP000007646","gene":"PCGF2","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"5be2b93f74851266da258b611f3d2a929a6fd262","counters":{"domain_architectures":7472,"entries":15,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"cdd":2,"ssf":1,"pfam":2,"smart":1,"profile":1,"panther":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":7472}}}