{"metadata":{"accession":"G3T117","id":"G3T117_LOXAF","source_organism":{"taxId":"9785","scientificName":"Loxodonta africana","fullName":"Loxodonta africana (African elephant)"},"name":"2-amino-3-carboxymuconate-6-semialdehyde decarboxylase","description":["Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway"],"length":336,"sequence":"MKIDIHSHILPKEWPDLNKRFGYGGWVQLQHHNKGEAKMLKDGKVFRVVQENCWDPDVRIREMDQTGVTVQALSTVPVMFSYWAKPLDTLDLCQLLNNDLAATVACHPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGSHVNEWDLNAQELFPVYAAAERLNCSLLVHPWDMQMDGRMAKYWLPWLVGMPAETTMAICSMIMGGVFTKFPKLKVCFAHGGGAFPFTLGRISHGFSMRPDLCAQDNPTNPKKYLGSFYTDSLVHDPLALKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEAFDEETKDKLKAGNALAFLGLERKQFE","proteome":"UP000007646","gene":"ACMSD","go_terms":[{"identifier":"GO:0016787","name":"hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016831","name":"carboxy-lyase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"893f5bb5f82dba8c120faf41d4a977fe8fba5622","counters":{"domain_architectures":79182,"entries":8,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":1,"pfam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":79182}}}