{"metadata":{"accession":"G3I5F7","id":"G3I5F7_CRIGR","source_organism":{"taxId":"10029","scientificName":"Cricetulus griseus","fullName":"Cricetulus griseus (Chinese hamster)"},"name":"Ragulator complex protein LAMTOR4","description":["As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated"],"length":99,"sequence":"MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASTISELVSTACGFRLHHGTNVPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV","proteome":"UP001108280","gene":"Lamtor4","go_terms":[{"identifier":"GO:0032008","name":"positive regulation of TOR signaling","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0071230","name":"cellular response to amino acid stimulus","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0071986","name":"Ragulator complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":null,"counters":{"domain_architectures":0,"entries":2,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"panther":1,"interpro":1},"proteome":1,"taxonomy":1}}}