{"metadata":{"accession":"G3I4A0","id":"G3I4A0_CRIGR","source_organism":{"taxId":"10029","scientificName":"Cricetulus griseus","fullName":"Cricetulus griseus (Chinese hamster)"},"name":"Actin, cytoplasmic 1","description":["Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules"],"length":723,"sequence":"IGPMSDHSDVSLPPQDRVRILSQLGSAVELNEDIPPRRYFRSGVEIIRMASVYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAIIPEKKDAVKKLKNVAFPKAEELKTELLKRYTKEYEQYKEQKKKEEEELARNIAIQQELEKEKQRVAQQKQKQLEQEQFHAFEEMIQKQELEKERLKIVQEFRKVDPGPCGPLLPDLEKPCVDTVPTSPMQTADRNRTVRPAKPPVVDRSLKPGALSIIENVPTIEGLRHIVVPRNLCSEFLQLASANTAKGIETCGVLCGKLMRNEFTITHVLIPRQNGGPDYCHTENEEEIFFMQDDLGLLTLGWIHVLQALAHSATSTMCEEETTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKPEYDEAGPSIVHRKCF","proteome":null,"gene":"I79_018277","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008233","name":"peptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008237","name":"metallopeptidase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f7242ae71c3a5f0e6af73a312198ef9600bab727","counters":{"domain_architectures":5,"entries":23,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"pfam":3,"ssf":3,"smart":1,"cdd":1,"panther":1,"prosite":3,"prints":1,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":5}}}