{"metadata":{"accession":"G1SFI0","id":"G1SFI0_RABIT","source_organism":{"taxId":"9986","scientificName":"Oryctolagus cuniculus","fullName":"Oryctolagus cuniculus (Rabbit)"},"name":"Glucose-6-phosphate isomerase","description":["In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion"],"length":530,"sequence":"MAALTRNPQFQKLQQWHREHGSELNLRHLFDTDKERFNHFSLTLNTNHGHILLDYSKNLVTEEVMHMLLDLDRAVLHVALRNRSNTPIVVDGKDVMPEVNKVLDKMKAFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPRVWFVSNIDGTHIAKTLACLNPESSLFIIASKTFTTQETITNAETAKDWFLLSAKDPSTVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLAMLGIWYINCFGCETQAVLPYDQYLHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILQALGKSYHPGCFRCSVCNECLDGVPFTVDAESNIYCVRDYHTVFAPKCASCARPILPAQVGSSRRPQVLGHDGREERPLWLFNLQRHGASVGPMPVGAGAPGMSQQDMVASVTQHSAYHPQPHAPPLG","proteome":"UP000001811","gene":"GPI","go_terms":[{"identifier":"GO:0097367","name":"carbohydrate derivative binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:1901135","name":"carbohydrate derivative metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004347","name":"glucose-6-phosphate isomerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006094","name":"gluconeogenesis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006096","name":"glycolytic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"0c2dd50e8712b1dc577c306d24189951b6315562","counters":{"domain_architectures":37545,"entries":22,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"profile":2,"cathgene3d":1,"pfam":1,"cdd":3,"smart":1,"hamap":1,"ncbifam":1,"panther":1,"prosite":1,"prints":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":37545}}}