{"metadata":{"accession":"G1P549","id":"G1P549_MYOLU","source_organism":{"taxId":"59463","scientificName":"Myotis lucifugus","fullName":"Myotis lucifugus (Little brown bat)"},"name":"PAS domain-containing serine/threonine-protein kinase","description":["Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation"],"length":1291,"sequence":"MEDRGSPALEKDWRCLCGNPSSLAPSEGPAVQTSPQLSKSVSSAHRHLNRRNGLSKLCQSRMALSEDRWSSYCLSSLAAQNICTGKVQCTAMAEQADPAGFLGSMSCCSLLRGLSSGCSTPLLPAPAGNPNKAIFTVDAKTSEILVANDNACRLLGYSSHDLIGLKLTQFFLKPDCDVVEALSEEHVEADGHAAVVFGTVVDVVSRSSERIPVSVWMKRMKQEPRLCCVVVLEPVERVSAWVSFQSDGTITSCDSVFAHLHGYECGNEVAGQRITDLIPSVQLPAPGQPLPQNLKIQRSVGRAKDGTTFPLSLKLKPKPNSKEAEAGQAAPEQGYSASIWVFSTISGLITLLSDGTIYGINHSFALMLFGYGRTELLGKNITFLIPGFYRCMDLVNEGSLPLPDLVSRLDMGNRSEPGETTVDPLQGWSTAEVGGRDPGINVMLAVDHMLPPDRTPKPAGSQEVVTGTQTQVDTGVRLPSPLSSLPTLGFQDIPEGSPPAHRQLSSPEDQQDTVLEKQEPTGTESLRQELLRGSRSASVDIRPFASCEDSEALTPAEDRSWGEVCGLSQAAQLECMGLSTANHQADAAGQLAEVGLPVLHPGYGAEWSTPQGSPATAASPSGPSGTARLSCSIPLEEQWLGAQDDREELQTCLLKEQLSKSSFGRPQDISSIELVPAEHTAFSTPVSLCDLGGRDLYSGHSGSSSAYYALATDLPGVLDTVEAPEADGNSFLWNLREVFYSRWTDRTSSNCSCASSELVGTASPSLAGSDVDVSTLHGHRAEVLDDRELLLLTGTYFNLGEGRQFCETHLGLNQREPSDTSECEDVSGRESPGCVLPRLESSPMDMCPLEEPRSSIQVTSTPVRGDSSATSGTTSLQQEIQEGTYLGSCCHRDGSLLSVQFEVKRVELQGPAPLFCCWLVKNLLHGQQASATHTQLLLASLPSSTHSACEHPGPSPGEMLRSRPWFEEPPKAGELEGLAACEGAYSHKYSTLSPLGSGAFGFVWTALDRDQNKEVVVKFIKKEKVLEDCWIEDPTLGKVTLEISILSRVEHANIIKILDIFENQSFFQLVMEKHGSGLDLFAFIDHHPSLDEPLASYIFRQLVSAVGYLRSKSILHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYKGPELEMWSLGVTLYTLIFEENPFCELEETLEAAINPPYLVSEDLMNLMSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVCGINKPESRVMSTVSLEVESRSPSEVAQHPELAAPP","proteome":"UP000001074","gene":"PASK","go_terms":[{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"354f65c5ffd892829338c1d929589b1e01ec0bc3","counters":{"domain_architectures":3105,"entries":23,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"smart":2,"cathgene3d":3,"ncbifam":1,"ssf":2,"pfam":2,"cdd":2,"profile":2,"panther":1,"prosite":2,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":3105}}}