{"metadata":{"accession":"G0ZAK6","id":"G0ZAK6_TUPBE","source_organism":{"taxId":"37347","scientificName":"Tupaia belangeri","fullName":"Tupaia belangeri (Common tree shrew)"},"name":"Apolipoprotein A-V","description":["Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin"],"length":369,"sequence":"MASTAALLTWALALLSAFSATQAQKGFWDYFSQSSGDKGMGEQIRQQKLAREPASLKDSLEQNLNNMDKFLEKLGPLSGQGRETPQFPQDPVGMRQQLQEELEEVRARLEPYMAEAHERVGWNLEELRQQLKPYTVELMEQVALRAQELQEQLRVVGEDTKAHLMGGVDEVRSLLQELQSRVAHHTGRVKELFHPYAERLVSGIGRHVQELHRSVAPHTPASPKRLSRCVQILSRKLTLKAKALHEHIQQNLDQLRKELSVFARANTNPAEEGAGPDPQVLSEEVRQRLQAFRHNTFLQIAAFTHAIDKETEEVQQQLAPPPPGHHAFAPEWQTDSDKALSRLQDRLDDLWEDITYSLHDQGHSHLGDP","proteome":null,"gene":"apoAV","go_terms":[{"identifier":"GO:0008289","name":"lipid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006869","name":"lipid transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0042157","name":"lipoprotein metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005576","name":"extracellular region","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"30784adefa18264133d315e6a3bdb7a3148aa7d2","counters":{"domain_architectures":445,"entries":6,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"interpro":2},"proteome":0,"taxonomy":1,"similar_proteins":445}}}