{"metadata":{"accession":"F7EMQ4","id":"F7EMQ4_ORNAN","source_organism":{"taxId":"9258","scientificName":"Ornithorhynchus anatinus","fullName":"Ornithorhynchus anatinus (Duckbill platypus)"},"name":"F-BAR and double SH3 domains protein 2","description":["Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes"],"length":708,"sequence":"MQPPPRKVKVTQELKNVQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGIQKLASQYLKKDWPGTKAEERSDSRSMYPVWKAFLEGTVQVAQSRINICDNYKNLISEPARAVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYLETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLLNIMKALDGNVSDHLKDYLMAFSRTELETCQAVQSTFQFLLETSSRSRQLESETGTTEEHSLNKEARKWATRIAREHKNIVHSQRTLDELECHGITVPEQNRAELEQKIDETRESIRKAEVVKLKAEARLGLLKQIGVSVDAWLKSAMNQVTEELENERWANLPSGTKNGSLHTLNADAERDEGDELEDSMDVFDDSSSSPSGTLRNYPLTCKVLYSYQASQPDELTIGEQEVLEVIEDGDMEDWVKARNQAGQVGYVPEKYLQFPTSSSLLSMLQSLAVLDGRSHASGSSPEADLGSGSLNGDSAVCFVKALYDYEGQTGDELTFPEGAIIRIVNKENQDDDGFWEGEFNGRVGVFPSVLVEELNASPNGGSLWSGEVQGSPSSKAQTSLAPLPLYDQPPSSPYPSPDRRTSPGFPSSPSVNENSLGSDSPAFPQPPRPAPEASYGKLRPVRAAPPPPTQSHRRPTEKMEDVEITLV","proteome":"UP000002279","gene":"FCHSD2","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a545e59474122de2c8795c9e23b2950f014b5090","counters":{"domain_architectures":2028,"entries":24,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"profile":2,"cathgene3d":2,"smart":2,"cdd":3,"ssf":2,"pfam":3,"panther":1,"prints":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":2028}}}