{"metadata":{"accession":"F7CCI7","id":"F7CCI7_HORSE","source_organism":{"taxId":"9796","scientificName":"Equus caballus","fullName":"Equus caballus (Horse)"},"name":"Multifunctional fusion protein","description":["Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore"],"length":268,"sequence":"MAAVPDTSDMMTYCSGNENDLFFEEDGPKQMKGSFQDLDLSSMGDGGIQLQISHHLYNKTFKHAMSIIVAVEKLKKIPVPCSQAFQDDDLRSLFSVIFEEEPIICDNWDEGYVCDAAMHSVNCRLRDIYHKSLVLSGACELQAVHLNGENTNQQVVFCMSFVQGEEETDKIPVALGLKGKNLYLSCGTKDGKPILQLETVDPNTYPKRKMEKRFVFNKMEIKGNVEFESAMYPNWYISTSQAEKKPVFLGNTRGGQDITDFIMEITSA","proteome":"UP000002281","gene":"IL1B","go_terms":[{"identifier":"GO:0005125","name":"cytokine activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006954","name":"inflammatory response","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006955","name":"immune response","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005615","name":"extracellular space","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005149","name":"interleukin-1 receptor binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"eca67f31d16121c20fb6a444eefb266f5c7eeb75","counters":{"domain_architectures":865,"entries":16,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"smart":1,"cdd":1,"ssf":1,"pfam":2,"panther":1,"prints":4,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":865}}}