{"metadata":{"accession":"F7BYT2","id":"F7BYT2_HORSE","source_organism":{"taxId":"9796","scientificName":"Equus caballus","fullName":"Equus caballus (Horse)"},"name":"YEATS domain-containing protein 4","description":["Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell"],"length":225,"sequence":"MFKRMAEFGPDSGGRGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQTKEI","proteome":"UP000002281","gene":"YEATS4","go_terms":[{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"dbfed5ef56370014162cd11931c80794560891b9","counters":{"domain_architectures":6988,"entries":8,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cdd":1,"cathgene3d":1,"pfam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":6988}}}