{"metadata":{"accession":"F7B0K1","id":"F7B0K1_CALJA","source_organism":{"taxId":"9483","scientificName":"Callithrix jacchus","fullName":"Callithrix jacchus (White-tufted-ear marmoset)"},"name":"Store-operated calcium entry-associated regulatory factor","description":["Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions"],"length":341,"sequence":"MAAACGPGTAGYCLLLGLHMFLLTAGPALGWNDPDRMLLRDVKALTLHYDRYTTSRRLDPIPQLKCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLKKLKESGKQHGFASFSDYYHKWYSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPSYSDYSTFSPRYQRFTNPSGPPPPGFKSEFTGPQNTGRGATSGFGGAFAGQQGYENSGPGFWTGLGTGGLLGYLFGSNRAATPFSDSWYYPSYPPSYSGTWNSRAYSPLRGGSGSYSACSNSDTKTRTASGNSFGNFRR","proteome":"UP000008225","gene":"SARAF","go_terms":[{"identifier":"GO:2001256","name":"regulation of store-operated calcium entry","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005789","name":"endoplasmic reticulum membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d7370caaadf6922c1aee2c98c0eaf0bbc9ee50a5","counters":{"domain_architectures":2885,"entries":3,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"panther":1,"pfam":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":2885}}}