{"metadata":{"accession":"F6X9U3","id":"F6X9U3_ORNAN","source_organism":{"taxId":"9258","scientificName":"Ornithorhynchus anatinus","fullName":"Ornithorhynchus anatinus (Duckbill platypus)"},"name":"Lethal(3)malignant brain tumor-like protein 1","description":["Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis"],"length":847,"sequence":"MDGRVELEVLRTPQGPGEVSVHLVASDNAVPTPHLPATAFIIPANPTTITLPTGPVEIQRFPREPLRGPGPERPERLPGSEPVTATVIPQVGGVQACSTVRVLEWKDGLATLPGSSLRLRINEFGTLKVVSGDRLAGPEPVTEAPPAKDGVPAGPTEHAAPAPPPGAEEDEEEEEEEEEEEEGSCRCNTCGRRHVAGGTRGGRGFCSEICHRQFTERSVIVENSAGSTNAVEILKPVKKRKRKECPSPSEGESELEQMEEKQEEQKDAEGEGDPATSTPESEEWSPSHPGPGGEPKDGWSWTAYLAEHKAVAAPPNLFQEHQRVSSHRNGFRPGMKLEGIDPQHPSMYFILTVAEVCGFRMRLHFDGYSECHDFWLNADSPNIHPAGWFERTGHKLQPPKGYKEDEFSWSNYLRVTKAQAAPQHLFVTPRSGVAPAGFQVGMKLEAVDRMNPSLICVATVTDVVDARFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQEHGKPLTPPQDYPDPDSFSWERYLGETGAPAVPAWAFTVRPPHGFLVNMKLEAVDRRSPSLIRVASVEDVEDHRVKIHFDGWTHAYDFWIDADHPDLHPAGWCSRTGHPLQPPLRPKEPGSSSSPPGSCPALNCKNLPPAKGSRYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAEKNQGRLKAELSDAEASARKRNLIGFSQRKKSRHHGRIGRPRKYRKLQQEDFQTLSADTGHQSFFMSALSAHPDRSLSLCWEQHCKLLPGVAGITAATVAKWTIDEVFGFVQTLTGCEDQAKLFKDEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNADDTLK","proteome":"UP000002279","gene":"L3MBTL1","go_terms":[{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"97ae16095e572273c51b110483ea58539d9f0210","counters":{"domain_architectures":1967,"entries":27,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"smart":2,"profile":3,"cathgene3d":3,"cdd":4,"ssf":3,"pfam":3,"panther":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":1967}}}