{"metadata":{"accession":"F6VBB2","id":"F6VBB2_MONDO","source_organism":{"taxId":"13616","scientificName":"Monodelphis domestica","fullName":"Monodelphis domestica (Gray short-tailed opossum)"},"name":"Tyrosine--tRNA ligase","description":["Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1"],"length":528,"sequence":"MGDVLTPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKSMLESIGVSLEKLKFVKGTDYQLSKEYTLDVYRLSSMVTQHDAKKAGAEVVKQVEYPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKXXXXXXYSKRIHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLAFIRHVLFPLKSEFVILRDEKWGGNKTYTAYSELEKDFANQVVHPGDLKNSVEVALNKLLDPIRERFNAPALKKLSSAAYPDLTKQKPMAKGCAKNSEPEEVIPSRLDIRVGKVISVEKHPDADSLYLEKIDVGEPEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASMEGTNRQVELLDPPSGSAPGERVFVEGYDKGQPDDELKPKKKVFEKLQADFKISSECIAQWKQTNFMTKLGFVSCKTLKGGSIS","proteome":"UP000002280","gene":"YARS1","go_terms":[{"identifier":"GO:0000166","name":"nucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004831","name":"tyrosine-tRNA ligase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006437","name":"tyrosyl-tRNA aminoacylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0000049","name":"tRNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004812","name":"aminoacyl-tRNA ligase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006418","name":"tRNA aminoacylation for protein translation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"d56b19848b0895c285ab1134a6cf1d156067198c","counters":{"domain_architectures":1515,"entries":19,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":2,"cdd":2,"profile":1,"pfam":2,"ncbifam":2,"panther":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":1515}}}