{"metadata":{"accession":"F6V2H7","id":"F6V2H7_HORSE","source_organism":{"taxId":"9796","scientificName":"Equus caballus","fullName":"Equus caballus (Horse)"},"name":"Programmed cell death protein 4","description":["Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA"],"length":479,"sequence":"MWEWSAIILVMLARARSWKDLKLQDPDNLSDSLFSGDEENTGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSRDSGRGDSVSDNGSEALRSGVTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDETAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTNDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIVMVLESTGESTFKMILDLLKSLWKSSTITLDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY","proteome":"UP000002281","gene":"PDCD4","go_terms":[{"identifier":"GO:0045892","name":"negative regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"dfcd58296e6dd908385e49aeb185a7559357033b","counters":{"domain_architectures":2405,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"profile":1,"pfam":1,"smart":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":2405}}}