{"metadata":{"accession":"F6UJG8","id":"F6UJG8_HORSE","source_organism":{"taxId":"9796","scientificName":"Equus caballus","fullName":"Equus caballus (Horse)"},"name":"N-lysine methyltransferase SETD6","description":["Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Required for the maintenance of embryonic stem cell self-renewal. Methylates PAK4"],"length":515,"sequence":"MFSEGMTSPGANPHSSSAWRPQPASRGPGAEAGTYAPPRGVAWDAGSVSAGLVTRGAGCPRTMATRAKRRRVAGPAGGGNPDPVAGFLSWCRRVGLELSPKVAVSRQGTVAGYGMVAQESVQPGELLFAVPRAALLSQHTCSISGLLERERGALQSQSGWVPLLLALLHELQAPASPWSPYFALWPELGRLEHPMFWPEEQRRQLLQGTGVPEAVEKDLANIRSEYYSIVLPFMEAHPDLFSPRVRSPELYHQLVALVMAYSFQEPLEEEEDEKEPNSPLMVPAADILNHLANHNANLEYSPNCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFVEPYPDNTDDTADIQMVTVREAALQGTKVEAERLLLYERWDFLCKLEMVGEEGAFVIGREEVLTEEELTTTLKVLCMPAEEFREFKDQDGWADDKKEEDSLTITNIPKLKASWRQLLRKSVLLTLQTYATDLKTEQDLLSNKEVYAKLSWREQQALQQSEVCSRWHNSPFREETLRHQ","proteome":"UP000002281","gene":"SETD6","go_terms":[{"identifier":"GO:0016279","name":"protein-lysine N-methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0018022","name":"peptidyl-lysine methylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0018026","name":"peptidyl-lysine monomethylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6fbac7c55e0ddca9cc62a2fd9a18d3682d927bf9","counters":{"domain_architectures":6516,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":1,"profile":1,"pfam":2,"pirsf":1,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":6516}}}