{"metadata":{"accession":"F6U3Z2","id":"F6U3Z2_HORSE","source_organism":{"taxId":"9796","scientificName":"Equus caballus","fullName":"Equus caballus (Horse)"},"name":"Amyloid beta precursor like protein 1","description":["May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I","The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis"],"length":652,"sequence":"MGPASPATRGLGRRRGPPPLPLLLPLSLLLLRAQLAVGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGARGGRCAHPHHQVVPFHCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGTDRFRGVEYVCCPPPVTPNPSGTAVGDPSTRSWPPGSRVEGVEDEEEEESFLQPVDDYFVEPPRAEEEEEEKAPPSSSHTPAGVSKVTPTPRPTDGVDVYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQGDLPQPERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVQTHLQVIEERMNQSLGLLDQNPQLAQELRPQIQELLHSEHLGPNELEAPAPAGSSEDKGELQPLDSKDADTPMALPKGSTEQDAASPGKENMSPLEQYERKVNVSVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSLLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP","proteome":"UP000002281","gene":"APLP1","go_terms":[{"identifier":"GO:0008201","name":"heparin binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0046914","name":"transition metal ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"9de1e266e3e584c01d58ea56cfb911de011004fe","counters":{"domain_architectures":2045,"entries":28,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"smart":1,"profile":2,"ssf":3,"pfam":4,"panther":1,"prints":1,"prosite":2,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":2045}}}