{"metadata":{"accession":"F6TPM0","id":"F6TPM0_ORNAN","source_organism":{"taxId":"9258","scientificName":"Ornithorhynchus anatinus","fullName":"Ornithorhynchus anatinus (Duckbill platypus)"},"name":"E3 ubiquitin-protein ligase RNFT1","description":["E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis"],"length":399,"sequence":"MQASYSHLHNPSGTGGGEAASASQCTHVPRLTGEGACHHTGDVHIQINSVPGEGGENSSSRYTRSSSQSCSHGRVHSRARGHSHNEARQPDEASVDSGEHGNSSISEFRYLFQWLQKSLPYILILCFKVVVQHITGISLGIGLLTTFMYANKSIVNQVFLREKCSKIQCAWLLVFLTGSSVLLYYTFHSQTLYHSLIFLNPSLDFLNFWDVLWIVGITDFILKFLFMGFKCLILLVPSFVMSFKSKGYWYMLLEELCQYYRTFVPIPVWFRYLVSYGELDSAAGWSLGVLLGLLYLILKLLDFFGHLRTFRRVLKTFFTQPNYGVTASKRQCSEADDLCSICQAEFQKPILLICQHIFCEECISLWFTRERTCPLCRTVISDHVSKWKDGATSSHLQIY","proteome":"UP000002279","gene":"RNFT1","go_terms":[{"identifier":"GO:0061630","name":"ubiquitin protein ligase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:1904294","name":"positive regulation of ERAD pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"12d1433dab545f19dde570dfa64f329161db0550","counters":{"domain_architectures":151903,"entries":12,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"ssf":1,"pfam":1,"smart":1,"profile":1,"panther":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":151903}}}