{"metadata":{"accession":"F6THE7","id":"F6THE7_ORNAN","source_organism":{"taxId":"9258","scientificName":"Ornithorhynchus anatinus","fullName":"Ornithorhynchus anatinus (Duckbill platypus)"},"name":"Association with the SNF1 complex (ASC) domain-containing protein","description":["Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)"],"length":275,"sequence":"MGNTASERLSGERHGSKWHRGEGAAAAHGPAKDQPHKIMVGSADDPSLFSLSDSKLPGDRDFVSWPQDLEESVRPLQQARPTVIRWSEGGREVFISGSFNNWSAKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQWVHDPSEPMVTSQLGTINNWIQVKKSDFEVFDALKLDSLESSETSCRDLSGSPPGLYGQEMYVFRSEERSRAPPILPPHLLQIILNKDTNISCDPALLPEPNHVMLNHLYALSIKDSVMVLSATHRYKKKYVTTLLYKPI","proteome":"UP000002279","gene":"PRKAB2","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"850be910b9cd318f3ca2b561f721d758cdaf390e","counters":{"domain_architectures":6674,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":1,"smart":1,"panther":1,"pfam":2,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":6674}}}