{"metadata":{"accession":"F6RLS7","id":"F6RLS7_MONDO","source_organism":{"taxId":"13616","scientificName":"Monodelphis domestica","fullName":"Monodelphis domestica (Gray short-tailed opossum)"},"name":"Ventral anterior homeobox 2","description":["Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina"],"length":343,"sequence":"MLAPAAAAAAGSMGDGGAEQGRGPIELASAERMRDLGSRAELGSTGRTGDWASGGAEGGGGGGREGGGGGGSRGLKDVAGTSATSPPAGSKTTCTESERQAGANEADYCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQSRDSEKHSSTSTSEAFATSNILRLLEQGRLLSVPGASSLLALTSTPPGLTTSNGATPLGLPRNSSSNLTGTSPTESPPKAGATFGLIGPQMASTSTSPRLPPPPPPLCFTTTPLLDLPSGYELGTSAFEPYSRLERKNSGPGSKKANTT","proteome":"UP000002280","gene":"VAX2","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000981","name":"DNA-binding transcription factor activity, RNA polymerase II-specific","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"1cca9db9652b5e6e0313f2eed7be72cec278d12f","counters":{"domain_architectures":145457,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"profile":1,"smart":1,"pfam":1,"cdd":1,"panther":1,"prosite":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":145457}}}