{"metadata":{"accession":"F6KD02","id":"F6KD02_HUMAN","source_organism":{"taxId":"9606","scientificName":"Homo sapiens","fullName":"Homo sapiens (Human)"},"name":"Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN","description":["Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3"],"length":403,"sequence":"MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYXSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPXPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV","proteome":null,"gene":null,"go_terms":[{"identifier":"GO:0016791","name":"phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016311","name":"dephosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016314","name":"phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051717","name":"inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051800","name":"phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008285","name":"negative regulation of cell population proliferation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0046856","name":"phosphatidylinositol dephosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"6c0458621e8ae2ef30ee0993d4f8b118aa51d371","counters":{"domain_architectures":2806,"entries":26,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":3,"ssf":2,"smart":3,"cdd":1,"pfam":2,"panther":1,"pirsf":1,"prosite":1,"interpro":10},"proteome":0,"taxonomy":1,"similar_proteins":2806}}}