{"metadata":{"accession":"F1RSE7","id":"F1RSE7_PIG","source_organism":{"taxId":"9823","scientificName":"Sus scrofa","fullName":"Sus scrofa (Pig)"},"name":"DNA replication licensing factor MCM4","description":["Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity","Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity"],"length":836,"sequence":"MSSPASTPSRRSTRRAAPTQPGQDPPSAGEPQLLPLSPGIELRSSPRAPSAGAPLDLDMSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSARKGLQVDLHSDGPAAEDIVASEQSLGQKLVIWGTDVNVATCKENFQRFIQRFIDPLAKEEENVGIDITEPLYMQRLGEINITGEPFLNVNCEHIKSFDTNLYRQLICYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLIAISGMVIRTSQLIPEMQEAFFQCQVCAHTARVEIDRGRIAEPGTCERCHTTHSMALIHNRSVFSDKQMIKLQESPEDMPAGQTPHTVVLFAHNDLVDKVQPGDRVHVTGIYRAVPIRINPRVSNVKSVYKTHIDVIHYRKTDSKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVTKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQAQEEVMDMAVLRDYIAYAHSTVLPRLSQDASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRFSNKVEAVDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITRDMFEEALRALADDDFLTVTGKTVRLL","proteome":"UP000008227","gene":"MCM4","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003678","name":"DNA helicase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006270","name":"DNA replication initiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0042555","name":"MCM complex","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0006260","name":"DNA replication","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a2f6e063ce1992646f63b89985e433c29cf8bb2c","counters":{"domain_architectures":3333,"entries":27,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"pfam":5,"ssf":2,"smart":1,"profile":1,"cdd":1,"panther":1,"prints":2,"prosite":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":3333}}}