{"metadata":{"accession":"E6ZJ99","id":"E6ZJ99_DICLA","source_organism":{"taxId":"13489","scientificName":"Dicentrarchus labrax","fullName":"Dicentrarchus labrax (European seabass)"},"name":"Mediator of RNA polymerase II transcription subunit 1","description":["Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors"],"length":587,"sequence":"MKSIISDLHLKFAEKTWNETFQLVRRCMDKSRDKSKPCEPLVRSLERLQEVFNVSSMNTMKSRLEMIAKQQGMGFHITEATCYLTADLFYLEVVLLPCGGVEDVKVAPHGGSPVPSESLLQLLRSKDFAEFSMKLAGVFTQYNIPGDNEIQLKLFASLQCLGNDLQQMSRLPNVPKESDPQVDMINNGRIGYLKAGKEDCPLIIQFYISPTDEMKTSDLYLTDTAVQAAQVTVGASDVAHKLQMASAISQPPQLDPQGYPVFLPLIEAQYEMLPACFLLKLQPGIPMMPSFVNKLSQITDVTIPDVDLQWAPLPKLLIRHSPSTNSLKEKLDEQDPIFTVPLPGGVMHSYVLPGAAWEVPAQRGAVVDSIPFTHPAHVPALLELLRHQCAINTLLRSCITSQGSVRDLHFEVLPESETSFSVTFHRPDTDSLAVLLVNVSDSHQISCTLFGAGIGDPSLDEYLSTVMKRCMSLPVTLRTLHSKLEEITSAPLSPRHPATTEAENDHSAASSTAATDPNSALTAISESASVPEDGLSVSGSACYAMSVAKSELLPEINISPAVNPYPFTPVGVFSHWMTKNSQLSELI","proteome":null,"gene":"MED1","go_terms":[{"identifier":"GO:0003712","name":"transcription coregulator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006357","name":"regulation of transcription by RNA polymerase II","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016592","name":"mediator complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3b49801674d0f409c789f70196aa78b0db568d11","counters":{"domain_architectures":3479,"entries":4,"isoforms":0,"proteomes":0,"sets":0,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"panther":1,"interpro":2},"proteome":0,"taxonomy":1,"similar_proteins":3479}}}