{"metadata":{"accession":"E6SII5","id":"E6SII5_THEM7","source_organism":{"taxId":"644966","scientificName":"Thermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)","fullName":"Thermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a)"},"name":"Endonuclease III","description":["DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate"],"length":271,"sequence":"MPPEERRRIARIRATLARMYPDATTALNWRTPFELLVATILSAQTTDAAVNQVTPALFARCPTPAAMLELTEDELGAMIRTIGLWRNKARNLLAACRILVERHGGQVPRTREELVQLPGVGRKTANVVLSNAFGIPAIAVDTHVFRVARRLGLASGTTPERVEQELMEKIPEAEWSRAHHWLIWHGRRICHARNPRCDLCALRPDCPTGQARLAAGNGDGTGPAEAAATGTPPGAPDQPVASGGRRPAAGGWRAVKPRGGPARDGHGPAAN","proteome":"UP000008915","gene":"nth","go_terms":[{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006284","name":"base-excision repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051539","name":"4 iron, 4 sulfur cluster binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003906","name":"DNA-(apurinic or apyrimidinic site) endonuclease activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ddd5072a1223698000690500e0e6a81f15308649","counters":{"domain_architectures":16761,"entries":21,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":2,"cdd":1,"pfam":2,"smart":2,"hamap":1,"panther":1,"ncbifam":1,"prosite":2,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":16761}}}