{"metadata":{"accession":"E2RKZ5","id":"E2RKZ5_CANLF","source_organism":{"taxId":"9615","scientificName":"Canis lupus familiaris","fullName":"Canis lupus familiaris (Dog)"},"name":"Programmed cell death 1 ligand 1","description":["The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy"],"length":289,"sequence":"MRMFSVFTFMAYCHLLKAFTITVSKDLYVVEYGGNVTMECKFPVEKQLNLFALIVYWEMEDKKIIQFVNGKEDLKVQHSSYSQRAQLLKDQLFLGKAALQITDVRLQDAGVYCCLIGYGGADYKRITLKVHAPYRNISQRISVDPVTSEHELMCQAEGYPEAEVIWTSSDHRVLSGKTTITNSNREEKLFNVTSTLNINATANEIFYCTFQRSGPEENNTAELVIPERLPVPASERTHFMILGPFLLLLGVVLAVTFCLKKHGRMMDVEKCCTRDRNSKKRNDIQFEET","proteome":"UP000805418","gene":"CD274","go_terms":null,"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7b38dac28088143820f932a79d156cf7b2e51fe2","counters":{"domain_architectures":6442,"entries":14,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"smart":1,"pfam":2,"profile":1,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":6442}}}