{"metadata":{"accession":"E2QYC9","id":"INADL_CANLF","source_organism":{"taxId":"9615","scientificName":"Canis lupus familiaris","fullName":"Canis lupus familiaris (Dog)"},"name":"InaD-like protein","description":["Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:17235357). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:15738264). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (PubMed:39112699). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (PubMed:17235357). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (PubMed:17235357). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (By similarity)"],"length":1828,"sequence":"MPENPAPDKLQVLQVLDRLKMKLQEKGDTSQNEKLSLFYETLQSPLFNQILTLQQSIKQLKGQLSHIPSDCSTNFDFSRKGLLVFTDSAITNGNAQRPSNNLTVSGLFPWTPKSGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGEVDIFVKEVQPGSIADRDQRLRENDQILAINHTPLDQNISHQQAIALLQQTTGSLHLVVAREPVHTKSRTSINLTDTTMPETVHWGHIEDVELINDGSGLGFGIVGGKSSGVVVRTIVPGGLADRDGRLQTGDHILKIGDTDVQGMTSEQVAQVLRNCGNSVRMLVARDPVGETSVTPPTPAALPVALPAVANRSPSTDSSLYETYGVELIKKDGQSLGIRIVGYIGTAHTGEASGIYVKSIIPGSAAYHNGQIQVNDKIVAVDGVNIQGFTNQDVVEVLRNAGQVVHLTLVRRKMCSSTSPLERSSDRGTVVEPSGTPARYVTGAVETETNLDGGDEETEERMDNLKNDNIQALEKLERVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGMEVDSFDGHHYISSIAPGGPVDALNLLQPEDELLEVNGVQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRTTETLLPEMEADHNVDINTEEEEEEELALWSPEVKIVELVKDHKGLGFSILDYQDPLDPTRSVIVIRSLVANGVAEKGGELLPGDRLVSVNEYCLENTTLAEAVEVLKAVPPGIVHLGVCKPLVDNDKEEESHYILHSNNNEDETELSETIHDINSSLILEAPKGFRDEPYYKEELVDEPFLDLGKAFQSQQKEIDNSKEAWEMQEFLPPRLQEMGEEREMLVDEECDLYQDHFQSMDLYPSSHLQEAAPVSSVKELHFGTQWLHDSEPPELQEARSMMNMYSQETQQYGYSTENMIKENFGIDSLPSISSSEGNSQQGRFDDLENLNSLTKSSLDLGMMIPNDVQGPGMLVELPAVAQRREQEDLPLYQLPRTRVVSKASAYTGASSSRYTAGACELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHREAVEAIKNAGNPVVFVVQSLSSTPRVIPSVHNKANKIANNQDQNTEEKKEKRQGTPPPPMKLPPPYKAPSDDSDENEEEYAFTNKKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAATDGRMRIGDELLEINNQILYGRSHQNASAVIKTAPSKVKLVFIRNEDAVNQMAVAPFPVPSSSPSSLEDQSGTEPVSSEEDGSLEVGIKQLPENESSKLEDISQVAGQGMVAGQQKALDCPTDNAVSQMKPQKYSTKVSFSSQEIPLAPAPSYHSTDVDFTSYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGRDTPLDAIVIHEVYEEGAAARDGRLWAGDQILEVNGIDLRSASHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDRRLIQGDQILSVNGEDMRNASQETVATVLKCAQGLVQLEIGRLRAGSWTSSRKTSQNSQGSQHSTHSSFHPSLAPVITSLQNLVGTKRATDPSLKSSGMDMGPRTVEIIRELSDALGISIAGGKGSPLGDIPIFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIATQLENMSTGYHLGSPTAEHHPEDTEEPLQMTAG","proteome":null,"gene":"PATJ","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3a9b984467d395e374c9da67447f879546d359b4","counters":{"domain_architectures":415,"entries":27,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"profile":2,"pfam":2,"smart":2,"cdd":10,"panther":1,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":415}}}