{"metadata":{"accession":"E1BSW6","id":"E1BSW6_CHICK","source_organism":{"taxId":"9031","scientificName":"Gallus gallus","fullName":"Gallus gallus (Chicken)"},"name":"Pleckstrin homology domain-containing family F member 1","description":["May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8"],"length":273,"sequence":"MVDHLANTEINSQRIAAVENCFGASGQPLAVPGRVLLGEGILTKECRKKPKPRIFFLFNDILVYGSIVINKRKYNSQHIIPLEDVTLETLPDTLQMKNRWMIKTSKKSFVVSAASLTERKEWISHLEECIRHLLTKTGRQPSTEHAAPWIPDKATDICMRCTQTKFSTLTRRHHCRKCGFVVCGDCSRQRFLMPRLSPKPLRVCNLCYRQLLAEQKKEEEADCQQPEQYRSAIPGYEPSSGDDSDKSDDYKVDQWPADTEFYTSEVSWSSFHS","proteome":"UP000000539","gene":"PLEKHF1","go_terms":[{"identifier":"GO:0046872","name":"metal ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"934138eaaecada7d8609be99db9164767204da69","counters":{"domain_architectures":2160,"entries":22,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cdd":2,"ssf":2,"cathgene3d":2,"profile":2,"smart":2,"pfam":2,"panther":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":2160}}}