{"metadata":{"accession":"D5JBX0","id":"GAO_HELAN","source_organism":{"taxId":"4232","scientificName":"Helianthus annuus","fullName":"Helianthus annuus (Common sunflower)"},"name":"Germacrene A hydroxylase","description":["Involved in the biosynthesis of germacrene-derived sesquiterpene lactones (PubMed:20351109). Catalyzes three consecutive oxidations of germacrene A to produce germacrene A acid (PubMed:20351109). Could also catalyze the three-step oxidation of non-natural substrate amorphadiene to artemisinic acid (PubMed:20351109)"],"length":488,"sequence":"MEVSLTTSIALATIVFFLYKLLTRPTSSKNRLPEPWRLPIIGHMHHLIGTMPHRGVMDLARKYGSLMHLQLGEVSAIVVSSPKWAKEILTTYDIPFANRPETLTGEIIAYHNTDIVLAPYGEYWRQLRKLCTLELLSVKKVKSFQSLREEECWNLVQEIKASGSGTPFNLSEGIFKVIATVLSRAAFGKGIKDQKQFTEIVKEILRETGGFDVADIFPSKKFLHHLSGKRGRLTSIHNKLDSLINNLVAEHTVSKSSKVNETLLDVLLRLKNSEEFPLTADNVKAIILDMFGAGTDTSSATVEWAISELIRCPRAMEKVQAELRQALNGKERIKEEEIQDLPYLNLVIRETLRLHPPLPLVMPRECRQAMNLAGYDVANKTKLIVNVFAINRDPEYWKDAESFNPERFENSNTTIMGADYEYLPFGAGRRMCPGSALGLANVQLPLANILYYFKWKLPNGASHDQLDMTESFGATVQRKTELMLVPSF","proteome":null,"gene":"GAO","go_terms":[{"identifier":"GO:0004497","name":"monooxygenase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005506","name":"iron ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016705","name":"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0020037","name":"heme binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a02e61ba6c64bb9a9c779746e03a6c43264a16fb","counters":{"domain_architectures":520850,"entries":12,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"cdd":1,"panther":1,"prosite":1,"prints":2,"interpro":4},"proteome":0,"taxonomy":1,"similar_proteins":520850}}}