{"metadata":{"accession":"D4Z2G1","id":"LINB_SPHIU","source_organism":{"taxId":"452662","scientificName":"Sphingobium indicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S)","fullName":"Sphingobium indicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S)"},"name":"Haloalkane dehalogenase","description":["Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Has a broad substrate specificity since not only monochloroalkanes (C3 to C10) but also dichloroalkanes (> C3), bromoalkanes, and chlorinated aliphatic alcohols are good substrates (PubMed:10100638, PubMed:9293022). Shows almost no activity with 1,2-dichloroethane, but very high activity with the brominated analog (PubMed:9293022). Is involved in the degradation of the important environmental pollutant gamma-hexachlorocyclohexane (gamma-HCH or lindane) as it also catalyzes conversion of 1,3,4,6-tetrachloro-1,4-cyclohexadiene (1,4-TCDN) to 2,5-dichloro-2,5-cyclohexadiene-1,4-diol (2,5-DDOL) via the intermediate 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (2,4,5-DNOL) (PubMed:7691794). This degradation pathway allows S.japonicum UT26 to grow on gamma-HCH as the sole source of carbon and energy"],"length":296,"sequence":"MSLGAKPFGEKKFIEIKGRRMAYIDEGTGDPILFQHGNPTSSYLWRNIMPHCAGLGRLIACDLIGMGDSDKLDPSGPERYAYAEHRDYLDALWEALDLGDRVVLVVHDWGSALGFDWARRHRERVQGIAYMEAIAMPIEWADFPEQDRDLFQAFRSQAGEELVLQDNVFVEQVLPGLILRPLSEAEMAAYREPFLAAGEARRPTLSWPRQIPIAGTPADVVAIARDYAGWLSESPIPKLFINAEPGALTTGRMRDFCRTWPNQTEITVAGAHFIQEDSPDEIGAAIAAFVRRLRPA","proteome":"UP000007753","gene":"linB","go_terms":[{"identifier":"GO:0018786","name":"haloalkane dehalogenase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4208e7859dea7ff67287230d6f84ba11d78c698d","counters":{"domain_architectures":386493,"entries":11,"isoforms":0,"proteomes":1,"sets":1,"structures":17,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"hamap":1,"ncbifam":1,"panther":1,"prints":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":386493}}}