{"metadata":{"accession":"D4ASL7","id":"D4ASL7_ARTBC","source_organism":{"taxId":"663331","scientificName":"Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)","fullName":"Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)"},"name":"Flap endonuclease 1","description":["Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA"],"length":359,"sequence":"MSIYSFLIAVRSDGQQLTNESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTMRKAEAQEAAEEAKETGTTEDVEKFSRRTVRVTKEHNAECKRLLGLMGIPYLDAPTEAEAQCAVLAKAGKVFGAASEDMDTLCFAAPVLLRHLTFSEQRKEPILEIHLDKVLEGLGMDMTQFVDLCILLGCDYLDPIPKVGPNTALKMIRDHGTLEKVVEAIQSDPKKKYVIPDDWPYLQARELFFNPDVRPADAPECDFKWSAPDVEGLVRFLVEEKGFSEDRVRNGAARLTKNLKSAQQSRLEGFFKPVAKTEEQKASAKRKAEEKAEAAKKKKKEDAKAKRAMTAKPRGAG","proteome":"UP000008866","gene":"ARB_07232","go_terms":[{"identifier":"GO:0004518","name":"nuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016788","name":"hydrolase activity, acting on ester bonds","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"65d1dc0c0ec0da2fac076aba8890f2d85fde3ea5","counters":{"domain_architectures":15963,"entries":24,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"smart":3,"cathgene3d":2,"cdd":2,"ssf":2,"pfam":2,"hamap":1,"panther":1,"prosite":2,"prints":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":15963}}}