{"metadata":{"accession":"D3B7L1","id":"D3B7L1_HETP5","source_organism":{"taxId":"670386","scientificName":"Heterostelium pallidum (strain ATCC 26659 / Pp 5 / PN500)","fullName":"Heterostelium pallidum (strain ATCC 26659 / Pp 5 / PN500) (Cellular slime mold)"},"name":"2-(3-amino-3-carboxypropyl)histidine synthase subunit 2","description":["Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit"],"length":602,"sequence":"MSEENNNNKQHVPLFFTDSSEVLLHDHDKDKAEKQAALEKQKEQQQMFSDDYFEIDTSAETIKRFSFKRVALQLPDSLLWAARTIVSHIESRCDNQCKVFILGDTSYGSCCVDEVTASHLKADFIIHYGHSCLSPATKLPVQYVFGKKTIDSDGFINSYKNQFKNDEKTIVFYSLEYSHQVKSISNSLKEYQSENVVITDIDNFNNIYYSQSFLNNNNNIDSDSSICNNNNTQQECCGQKDKESQQSTSCCSTDNNSNSNSCCSNTSTSSCSTNNNNNNNNNNNNSNDIDSKLVFGRKLSIDLKDIEQYKILWIGDECLTLTNLLMNFNKNNFYRYNPENNSIQQVTLSRNQSLMKRYYISNKCKEANIIGIVVATLTVQKYSETIDSLKKLIIKNGKKPYVFVVGRLNVPKLANFSEIDIFVIVACPENTIVDSKEYYKPIATPFELNLALSGNEWSGEYVTDFGKLFPRLVDQLSKDENNDNNKDNSNREERAEDDVSDDEGNRYHFSLTTGKIMKYYSNTSGINNNNNNQNSNNNGEIVSVDNKFKQLSTTGAATNASEYFAGRTYRGLETKIGETEVIKAVVGKTGIPKSYDNDIANQ","proteome":"UP000001396","gene":"dph2","go_terms":[{"identifier":"GO:0090560","name":"2-(3-amino-3-carboxypropyl)histidine synthase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0017183","name":"protein histidyl modification to diphthamide","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ea09e60cb3857d7aa4f8719208258581f4f0b8e0","counters":{"domain_architectures":827,"entries":13,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"ncbifam":2,"cathgene3d":2,"sfld":3,"panther":1,"pfam":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":827}}}