{"metadata":{"accession":"D2C190","id":"D2C190_DICZ5","source_organism":{"taxId":"590409","scientificName":"Dickeya zeae (strain Ech586)","fullName":"Dickeya zeae (strain Ech586)"},"name":"Formamidopyrimidine-DNA glycosylase","description":["Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates"],"length":269,"sequence":"MPELPEVETSRRGISPWLVGRTILYAEVRNARLRWPVSPEILSLSDTPVLSVQRRAKYLLLELPTGWIIIHLGMSGSLRVLPEYSEPDKHDHVDLVMDSGKVLRYTDPRRFGAWLWCDDLANSSVLAHLGPEPLSDDFSGDYLFSRCHGRKTPIKLWIMDNKLVVGVGNIYASESLFNAGILPERPAGSLSQQEAHQLVQSIKQVLQRSIEQGGTTLRDFLQSDGKPGYFAQELQVYGRNGKPCHHCGTLIDSIKQGQRSTFFCKRCQR","proteome":"UP000001446","gene":"mutM","go_terms":[{"identifier":"GO:0003906","name":"DNA-(apurinic or apyrimidinic site) endonuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019104","name":"DNA N-glycosylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006284","name":"base-excision repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003684","name":"damaged DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016799","name":"hydrolase activity, hydrolyzing N-glycosyl compounds","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008534","name":"oxidized purine nucleobase lesion DNA N-glycosylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"80cde816fdd044952e2dc733f0e587d4b1b6f0f6","counters":{"domain_architectures":26807,"entries":26,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"pfam":3,"profile":2,"smart":2,"cdd":1,"cathgene3d":2,"ssf":3,"ncbifam":2,"panther":1,"hamap":1,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":26807}}}