{"metadata":{"accession":"C1D6I2","id":"DNAA_LARHH","source_organism":{"taxId":"557598","scientificName":"Laribacter hongkongensis (strain HLHK9)","fullName":"Laribacter hongkongensis (strain HLHK9)"},"name":"Chromosomal replication initiator protein DnaA","description":["Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids"],"length":481,"sequence":"MTDLSAFWPQCLARFEAELSAQQFNTWIKPLVCVAGEDAIALYAANRFSLGFVKERFLSRIETFAEDILGRPVTIELRIGGAQAGASAPAAASPRSPGRPAPAPVAATPTTGSLADSIVSDVPLPNVKLTAPKPAIGGGHESTRLNPAFTFESLVTGKGNQLARAAALQIADNPGDSTYNPFFVYGGVGLGKTHLIQAIGNHVYQKNPQAKIRYIHAERYVADIMRAYQHKAFDEFKRYYHSLDLLLIDDIQFFAGKNRTMEEFFYAFNALLEGGKQVIMTCDSYPKQIEGMDERLISRFSWGLTVEIQPPELEMRVAILMKKAEADNLKLGNDVAFFIAQNVRSNVRELEGALKRVVAYSRFSNQPISLDLVKEALKDILAAGNRQISVDNIQKTVADYYKIKLSDMHSKKRSRDIARPRQVAMALAKELTSMSLPNIGDAFGGRDHTTVLHACKTIAEMRESDPDISRDYAALQQMLRN","proteome":"UP000002010","gene":"dnaA","go_terms":[{"identifier":"GO:0043565","name":"sequence-specific DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006270","name":"DNA replication initiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006275","name":"regulation of DNA replication","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003688","name":"DNA replication origin binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"af048913435faf44e3cf5dbae4bb1e79c0668ce6","counters":{"domain_architectures":17631,"entries":28,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"pfam":3,"ssf":2,"cdd":2,"smart":2,"panther":1,"hamap":1,"ncbifam":1,"prosite":1,"prints":1,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":17631}}}