{"metadata":{"accession":"B9IIA7","id":"B9IIA7_POPTR","source_organism":{"taxId":"3694","scientificName":"Populus trichocarpa","fullName":"Populus trichocarpa (Western balsam poplar)"},"name":"RING-type E3 ubiquitin transferase","description":["E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Mediates the proteasomal-dependent degradation of ATG6, a component of the autophagosome complex. Requires TRAF1A/MUSE14 and TRAF1B/MUSE13 to target ATG6 for ubiquitination and subsequent regulation of autophagosome assembly. Modulates directly the ubiquitination and proteasomal-dependent degradation of FREE1, a component of the ESCRT-I complex. Modulates directly the ubiquitination and proteasomal-dependent degradation of ELC/VPS23A, a component of the ESCRT-I complex"],"length":304,"sequence":"MAPGGSAFKEVLELVAECDIATSKSENNIAPTKGTVILSGKHGVYSNNGVHELLECPVCTNLMYPPIHQCPNGHTLCSACKLRVHNCCPTCRYDLGNIRCLALEKVAESLELPCKYQSLGCLDVFPYYSKLKHEQHCRFRPYSCPYAGSECSVTGDIPALAAHLKDDHKVDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDDNEAKKFSYSLEVGGNGRKLVWQGIPRSIRDSHRKVRDSQDGLIIQRNLALYFSGGDRKELKLRVTGRVWKEE","proteome":"UP000006729","gene":"POPTR_016G059700","go_terms":[{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006511","name":"ubiquitin-dependent protein catabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007275","name":"multicellular organism development","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3f468851f694fe28c25bcae276188b81757b837b","counters":{"domain_architectures":5800,"entries":19,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":2,"pfam":3,"profile":2,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":5800}}}