{"metadata":{"accession":"B7ZQ67","id":"B7ZQ67_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"G1/S-specific cyclin-D2","description":["Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals"],"length":291,"sequence":"MELLCCEGDTVRRAQPDPALLLDDRVLHNLLTVEERYLPQCSYFKCVQKDIQPFMRRMVATWMLEVCEEQRCEEEVFPMAMNYLDRFLAVIPTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPLPKDKLLLIRKHAQTFIALCATDFNFAMYPPSMIATGSVGAAICGLQLDVGETSLSGDSLTEHLAKITSTDVDCLKACQEQIESVLVSSLRQTRQQTQQRNSSKSVDELDQASTPTDVQDINL","proteome":"UP000186698","gene":"ccnd2.L","go_terms":[{"identifier":"GO:0016538","name":"cyclin-dependent protein serine/threonine kinase regulator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0044772","name":"mitotic cell cycle phase transition","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fd1efc4a1ce5c8e2dc0db0172d8c97e704be840e","counters":{"domain_architectures":39207,"entries":18,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cdd":2,"ssf":1,"cathgene3d":1,"pfam":2,"smart":2,"pirsf":1,"panther":1,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":39207}}}