{"metadata":{"accession":"B7UI22","id":"NLEE_ECO27","source_organism":{"taxId":"574521","scientificName":"Escherichia coli O127:H6 (strain E2348/69 / EPEC)","fullName":"Escherichia coli O127:H6 (strain E2348/69 / EPEC)"},"name":"Cysteine S-methyltransferase NleE","description":["Cysteine methyltransferase effector that inhibits host cell NF-kappa-B activation by preventing nuclear translocation of host protein RELA/p65 (PubMed:20126447, PubMed:20485572, PubMed:22158122, PubMed:25412445, PubMed:27445336). Acts by mediating cysteine methylation of host proteins TAB2 and TAB3: methylation of a conserved cysteine residue of the RanBP2-type zinc finger (NZF) of TAB2 and TAB3 disrupts zinc-binding, thereby inactivating the ubiquitin chain-binding activity of TAB2 and TAB3, leading to NF-kappa-B inactivation (PubMed:22158122, PubMed:25412445, PubMed:27445336). Also mediates cysteine methylation of host protein ZRANB3, inactivating its ability to bind ubiquitin chains (PubMed:25412445)"],"length":224,"sequence":"MINPVTNTQGVSPINTKYAEHVVKNIYPKIKHDYFNESPNIYDKKYISGITRGVAELKQEEFVNEKARRFSYMKTMYSVCPEAFEPISRNEASTPEGSWLTVISGKRPMGQFSVDSLYNPDLHALCELPDICCKIFPKENNDFLYIVVVYRNDSPLGEQRANRFIELYNIKRDIMQELNYELPELKAVKSEMIIAREMGEIFSYMPGEIDSYMKYINNKLSKIE","proteome":"UP000008205","gene":"nleE","go_terms":null,"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7bda791a46a38a1689028b92b92384b330ae2758","counters":{"domain_architectures":96,"entries":3,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"ncbifam":1,"pfam":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":96}}}