{"metadata":{"accession":"B6QCM3","id":"B6QCM3_TALMQ","source_organism":{"taxId":"441960","scientificName":"Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)","fullName":"Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)"},"name":"Actin cytoskeleton-regulatory complex protein END3","description":["Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization"],"length":406,"sequence":"MAKRIEQWEVERYWEIFSSLANGQSRLNNSQAASVLRNSRLRDDQLEKVWDLADVDGDGELDFEEFCVAMRLIFDLVNGEYQEVPRALPDWLIPESKAHLVQASAALTGRQEQFERIEDEDDTPGLKDGFDWYMSPADKAKYEEIYSANKNHRGEITFDSLQPLYDSLDVPDTDIRSAWNLVNPAASSSINKDASLAFLHILNFRHEGFRIPRTVPPSLRASFESNKIDYQVDNVRPAQKWGADGDTETTTGRKAKFGDTYLSRLGVKSTYRPQGTDFSNTIQDEEWEKVRLRRELAELEQKLEAANRVSDERRSGDASSSTRQDGRPNWAIIKKEALQLLEYKERELREMKEGTGRTKDGQDLERLREDIKTVADQVDGLKDHLDRRNEVLAELRRQIEDEKASR","proteome":"UP000001294","gene":"PMAA_067750","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006897","name":"endocytosis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007015","name":"actin filament organization","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"485a3a6bb3dfcff7f3bc3b18f8ddad09c4c2d1f8","counters":{"domain_architectures":1206,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"smart":2,"cathgene3d":1,"ssf":1,"pfam":2,"profile":2,"cdd":1,"panther":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":1206}}}