{"metadata":{"accession":"B6KA42","id":"B6KA42_TOXGV","source_organism":{"taxId":"432359","scientificName":"Toxoplasma gondii (strain ATCC 50861 / VEG)","fullName":"Toxoplasma gondii (strain ATCC 50861 / VEG)"},"name":"Thioredoxin reductase","description":["Catalyzes the transfer of electrons from NADPH to thioredoxins TRX1, TRX2 and TRX3, which in turn act as reductants of disulfide containing proteins. Able to reduce nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO); however, TRX1 is more efficient in reducing GSNO. Has no catalytic activity towards oxidized glutathione (GSSG)"],"length":662,"sequence":"MSCLSVSAARAYAAAAASRPVSASFLPAFSRLSQCSFLSENCVLRCTSSVYPASHSTHRTNDLQSTLSAVVLPERLPCTPLAHAAAVVAVWNSGSLLVSTPLFSVCRTETISCAPPAQRQQERAFASERKLSVISTNASEMAPTNTNNGAPSCADGEFDYDLAVIGGGSGGLACAKMAAAQGAETVVFDFVQPSTQGSTWGLGGTCVNVGCVPKYLFHHTGLAGANAHWDGPHMGWKGKFEEQVDWGVCVEKVQNYIKSLNFGYRTGLRKAGVTYINAYAKFVSPHELAYTFRGEDKICKARNIVVAVGGRPHIPEEVEGAKELAITSDDIFSLKQAPNKTLCVGASYISLECAGFLRELGFDVTVAVRSILLRGFDRQCAEQVGLCLEEAGVRILRETIPAKMVKQANGKIQVTFQVGKEKKELVEEFDTVLYATGRKADTSNLNLQAAGVETTETGKIVCDGDSHTSAPSVYAIGDAVENFPELTPVAIKAGEILARRLFANSTEHMDFTNIPTTVFTPIEYAHTGYSEEAAEAEFGRDDLEVYLFQFSPLFFSCVHREKAPQARKSPEDVDITPPCLAKLICVKSEDEKVVGIHFVGPNAGELMQGFALAVRLGAKKRDFDKCVGIHPTNAEAFMALTVTKASGEPFVASGGCGGGKCG","proteome":"UP000002226","gene":"BN1205_093780","go_terms":[{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0050660","name":"flavin adenine dinucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0045454","name":"cell redox homeostasis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004791","name":"thioredoxin-disulfide reductase (NADPH) activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016668","name":"oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"786e6e0af388e0b289d71a3e92e80414d4c849c2","counters":{"domain_architectures":105347,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":2,"pfam":2,"panther":1,"ncbifam":1,"prosite":1,"prints":2,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":105347}}}