{"metadata":{"accession":"B5RUG2","id":"B5RUG2_DEBHA","source_organism":{"taxId":"284592","scientificName":"Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)","fullName":"Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast)"},"name":"Threonylcarbamoyl-AMP synthase","description":["Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length"],"length":402,"sequence":"MLSKSHCWLINKTIIRRKVCCINSKMAFTTKILRANKDSIIFNKNDILPKITDPETEKSLRIAANELATSTNVVGFPTETVYGLGGSALNDESVKSIYKAKNRPADNPLIVHVSSIDQLKRKILPKDYKIPEIYDNLIEKFWPGPLTILLPIHEGSPISKIVTANQSTFAVRIPQHPIARALIALSDLPLAAPSANASTRPSPTLASHVYHDLQGKIPYIIDGGACDVGVESTVVDGLVDPPMLLRPGGVSVEDVRKTGGGSWENVVLAKKTAGKSEAVKTPGMKYKHYSPTAKVVLFINCGDGIAAISKYISENNIPESKTIALLKSRYFTDARAISRQINIEEDLGATGPEISRNLFKLLRQVDEQGVDIIFIEGIDETDEGLAVMNRLSKAAFETINGK","proteome":"UP000000599","gene":"DEHA2F13486g","go_terms":[{"identifier":"GO:0003725","name":"double-stranded RNA binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"877a1ee30afb12d45b91a707aea20dea704ee902","counters":{"domain_architectures":13298,"entries":15,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":1,"ssf":1,"pfam":2,"panther":1,"pirsf":1,"ncbifam":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":13298}}}