{"metadata":{"accession":"B4QZU6","id":"HTRA2_DROSI","source_organism":{"taxId":"7240","scientificName":"Drosophila simulans","fullName":"Drosophila simulans (Fruit fly)"},"name":"Serine protease HTRA2, mitochondrial","description":["Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th/Diap1 by directly inducing the degradation of th/Diap1 (By similarity)"],"length":422,"sequence":"MALRGCHRLEVIFKRCIASPVLHSQAGNRRSSQLAIKGVDPNSNGNSGQYQQNGEHKEKGWRRLVRFFVPFSLGAAVSAAIIQREDFTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPNNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITPEDP","proteome":"UP000000304","gene":"HtrA2","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004252","name":"serine-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a91117da869a35547876bcc310da68b803a7d944","counters":{"domain_architectures":4109,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"pfam":2,"cdd":1,"smart":1,"profile":1,"panther":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":4109}}}