{"metadata":{"accession":"B4JFD2","id":"B4JFD2_DROGR","source_organism":{"taxId":"7222","scientificName":"Drosophila grimshawi","fullName":"Drosophila grimshawi (Hawaiian fruit fly)"},"name":"Actin-related protein 2/3 complex subunit 3","description":["Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)","Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks"],"length":177,"sequence":"MPAYHSQIKDFRQQVGNMAILPLRTQVRGPAPSANVDSDIIDESLYFFKANVFFRTYEVKSEVDRVLIYITLYITECLKRLTRITSKAQGQQEMYSLAISKFDIPGDAGFPLNSVYAKPQTAQDADLMRQYLLQLRHETGNRVVEKVFSTEDGRPNKWWTCFAKKKFMEKSLAGPGQ","proteome":"UP000001070","gene":"Dgri\\GH19295","go_terms":[{"identifier":"GO:0034314","name":"Arp2/3 complex-mediated actin nucleation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005856","name":"cytoskeleton","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005885","name":"Arp2/3 protein complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d1017cf1b80e248e2fdb9c261faafb37841a752a","counters":{"domain_architectures":4324,"entries":7,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pirsf":1,"pfam":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":4324}}}