{"metadata":{"accession":"B2UQG6","id":"H0868_AKKM8","source_organism":{"taxId":"349741","scientificName":"Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)","fullName":"Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)"},"name":"Beta-N-acetylhexosaminidase Amuc_0868","description":["Potentially capable of cleaving the specific glycoside linkages in the process of mucin degradation in human intestinal tract (Probable). Hydrolyzes chromogenic substrates pNP-beta-GlcNAc with high activity and pNP-beta-GalNAc to a lesser extent, but not pNP-beta-glucose or pNP-beta-galactose (PubMed:32819592). May cleave terminal beta-(1,3)-linked GalNAc residues from extended B antigens (ExtB) on mucin O-linked glycans enabling bacteria to colonize nutritive niches in the host's gut"],"length":549,"sequence":"MISKCTFSATVFSLFSLCWGAPSSPVLEAPHTIPLPAAMRVQTGESGFSLKNGVRLPEKNPLSRQAERIFRDNGINTALVKNNADIIFTEDASLGREGYRLAVTPDSISIASGSVNGTLYALQSLVQSIAADKNGAPALPRMDVKDQPRFSWRGLMVDSCRHMMPVRDIKKVLDLMERYKFNTLHWHLTDDQGWRLPIAKYPRLTTVGGARAQSPVIGNRNKGDGIPYSGHYTADEIRDVVRYARDRGITVIPEVEMPGHASAAIAAYPELGNTDIPGYEPRVQETWGVHSYTFSPTEKTFRFLEDVIDEICALFPDSPYIHIGGDEAPKNQWKQSPTAQRVMKDNGLANEHELQSYFIRRVEKMINNRGKRLIGWDEIQEGGLSPTATMMVWRSQMPHIAAQALAQGNDIVMTPNSHLYFDYDQGPGKPAAPEYETINNNQLTWQHVYGLEPVPQGTPREREKQVLGCQANIWTEYIPNLPKWEYHVFPRALALAEVAWTPQELKNEKDFRKRLDRQLPFLDARGVNYKRPDNGAPAQPKAVITRERR","proteome":"UP000001031","gene":"Amuc_0868","go_terms":[{"identifier":"GO:0004553","name":"hydrolase activity, hydrolyzing O-glycosyl compounds","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005975","name":"carbohydrate metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004563","name":"beta-N-acetylhexosaminidase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4175614b488e6f62480b5bc8d42e36992a625e22","counters":{"domain_architectures":11295,"entries":15,"isoforms":0,"proteomes":1,"sets":3,"structures":2,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"pfam":2,"cdd":1,"panther":1,"pirsf":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":11295}}}