{"metadata":{"accession":"B0X072","id":"B0X072_CULQU","source_organism":{"taxId":"7176","scientificName":"Culex quinquefasciatus","fullName":"Culex quinquefasciatus (Southern house mosquito)"},"name":"Cystathionine beta-synthase","description":["Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons"],"length":539,"sequence":"MSDHRTCPMANGHNGTSSTNGGVDSREQFLAGFKRPDLASRCTWAVGTEEASPHQHRPLVPRPKVLQTILQAVGNTPLVKLNSIPKAANLKCNLYAKCEFMSPGGSVKDRIGLRMIEEAEKKGLLKPGYTIIEPTSGNTGIGLAMGAAVKGYRCLIVMPEKMSNEKVDTLKALGAEVIRTPTEAAFDSPEGLIAVAQRLEKEIPNSIVLNQYTNAGNPLAHYDGTGAEIVDQLEGQVDMVVVGAGTGGTVAGIGRKIKETNPDCVIVGADPEGSILALPDKLNESNVSFYEVEGVGYDFIPTVLDRSVVDRWIKFNDKDALPMARRLIAEEGFLCGGSSGGNVAVALEAAKELKEGQNCVVILPDNIRNYLTKFVSDNWMEARNFKPSVNVHKHKWWNNSLTTLDMTPPPTVGVDVCLQEVINIMQTAHVDHLPVLDGTTVKGMVSLPNLTSKLLNRLAKPSDPVSRAIFKQFVRVDQNDNVGHVSRILEKDAFVLVVKNEKTSDSQLKETVVGVLTQRDLLFYISNAQNVINGDGNSA","proteome":"UP000002320","gene":"6045737","go_terms":[{"identifier":"GO:0004122","name":"cystathionine beta-synthase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019343","name":"L-cysteine biosynthetic process via L-cystathionine","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0006535","name":"L-cysteine biosynthetic process from L-serine","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"264b54861be4f332a770a01279b6b265ce4430d9","counters":{"domain_architectures":5489,"entries":21,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cathgene3d":2,"cdd":2,"profile":1,"pfam":2,"smart":1,"ncbifam":1,"panther":1,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":5489}}}