{"metadata":{"accession":"A8WTJ7","id":"HOT_CAEBR","source_organism":{"taxId":"6238","scientificName":"Caenorhabditis briggsae","fullName":"Caenorhabditis briggsae"},"name":"Hydroxyacid-oxoacid transhydrogenase, mitochondrial","description":["Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG"],"length":465,"sequence":"MSASLARGMLHKMGGSCCPHHAPTTNPFRMAKLHGNNKSTDYAFEMVCSTLRFGKGVTLEIGYDVRNLGAKKTLLITDKNVQNTIAFKNAEQALKMVNIEYEIFDDVLIEPSEKSMQKAIAFAKSKPFDSFIAVGGGSVIDTTKAAALYASNPEADFLDFVGPPFGKSLQPKNPMLPLIAVPTTAGTGSETTAAAIMDLPEHKCKTGIRLRCIKPYLAVVDPLNVMSMPRNVAIYSGFDVLCHALESYTALPYDQRSPRPARPEVRPVYQGSNPISDVWSREALRIIGQYFRRSVFDPSDEEARTEMLKASSFAGIGFGNAGVHLCHGLSYPISSQAKGCVAHDYPQDKNLIPHGLSVMTTAVADFEFTTAACPDRHLVAAQTLGADIPNNADNEYISRTLCDQLRGFMKDFGVPNGLKGMGFEYSDIDHLTEAASHSVPNIVISPKSTDRDIISKLYEKSLTVY","proteome":"UP000008549","gene":"hphd-1","go_terms":[{"identifier":"GO:0004022","name":"alcohol dehydrogenase (NAD+) activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0046872","name":"metal ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"5b7a857fcd2426c102beb3316b28cb8a761cb0f0","counters":{"domain_architectures":54669,"entries":13,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":1,"cdd":1,"pfam":2,"panther":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":54669}}}