{"metadata":{"accession":"A8CEM1","id":"ASIP_MACCY","source_organism":{"taxId":"78449","scientificName":"Macaca cyclopis","fullName":"Macaca cyclopis (Taiwan macaque)"},"name":"Agouti-signaling protein","description":["Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptor MC1R, thereby playing a role in the regulation of melanogenesis (By similarity). Binding to MC1R prevents alpha-MSH-induced signaling and inhibits cAMP production, resulting in down-regulation of eumelanogenesis (brown/black pigment) and increased pheomelanin (yellow/red pigment) synthesis (By similarity)"],"length":132,"sequence":"MDVTRLLLATLLVFLCFFTAYSHPPPEEKLRDDRSLRSNSSVNLLDFPSVSIMALNKNSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC","proteome":null,"gene":"ASIP","go_terms":[{"identifier":"GO:0009755","name":"hormone-mediated signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005576","name":"extracellular region","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005102","name":"signaling receptor binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ea075f60af0c34057757a25b6b71a073b05f4e4e","counters":{"domain_architectures":2026,"entries":10,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"smart":1,"cathgene3d":1,"pfam":1,"profile":1,"ssf":1,"panther":1,"prosite":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":2026}}}