{"metadata":{"accession":"A8A5H5","id":"CYSG_ECOHS","source_organism":{"taxId":"331112","scientificName":"Escherichia coli O9:H4 (strain HS)","fullName":"Escherichia coli O9:H4 (strain HS)"},"name":"Siroheme synthase","description":["Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme"],"length":457,"sequence":"MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLDAGARLTVNALAFIPQFTAWADAGMLTLVEGPFDESLLDTCWLAIAATDDDALNQRVSEAAEARRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPLHLGQVAKYAGQLRGRVKQQFATMGERRRFWEKLFVNDRLAQSLANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQQKLIEHGMPGEMPVAIVENGTAVTQRVIDGTLTQLGELAQQMNSPSLIIIGRVVGLRDKLNWFSNH","proteome":null,"gene":"cysG","go_terms":[{"identifier":"GO:0006779","name":"porphyrin-containing compound biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008168","name":"methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019354","name":"siroheme biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004851","name":"uroporphyrin-III C-methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043115","name":"precorrin-2 dehydrogenase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051266","name":"sirohydrochlorin ferrochelatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051287","name":"NAD binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009236","name":"cobalamin biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"396b1b5768b7ef5c65858c076fd79ee5622a31ed","counters":{"domain_architectures":5061,"entries":35,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":5,"ssf":3,"pfam":4,"cdd":1,"pirsf":1,"hamap":1,"ncbifam":4,"panther":1,"prosite":2,"interpro":13},"proteome":0,"taxonomy":1,"similar_proteins":5061}}}