{"metadata":{"accession":"A7F5M4","id":"LSM6_SCLS1","source_organism":{"taxId":"665079","scientificName":"Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)","fullName":"Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)"},"name":"U6 snRNA-associated Sm-like protein LSm6","description":["Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity)"],"length":85,"sequence":"MENGALNQGEGKDPSSFLSDIIGSRVIVKLNNSLVFKGELQSVDGYMNIALEKCEEWVHGKKKTVHGDAFVRGNNVMYISADDSA","proteome":"UP000001312","gene":"lsm6","go_terms":[{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000398","name":"mRNA splicing, via spliceosome","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"83b18cf71a575d59c0de6840812ffe7912383fc4","counters":{"domain_architectures":70645,"entries":12,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"profile":1,"ssf":1,"smart":1,"pfam":1,"panther":1,"pirsf":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":70645}}}