{"metadata":{"accession":"A6W7N6","id":"ILVC_KINRD","source_organism":{"taxId":"266940","scientificName":"Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)","fullName":"Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)"},"name":"Ketol-acid reductoisomerase (NADP(+))","description":["Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate"],"length":342,"sequence":"MAEMFYDDDADLSTITGKKVAVLGFGSQGHAHALSLRDSGVDVVVGLKEGSKSRAKAEEQGLTVLTPFEASKAADVIMVLVPDHLQRGLYAEAIEPNLTAGKALFFSHGFNIRFGYIKPPADVDVVMVAPKGPGHLVRREYVDGRGVPVIVAVEQDATGQAWALALAYAKAIGGLRAGGIKTTFTEETETDLFGEQAVLCGGASALVQTGFEVLTEAGYQPEVAYFECLHELKLIVDLMYEGGIAKQRWSVSDTAEWGDYVSGPRVIDASVKERMKDVLKDIQDGTFARNFIEDQDAGAPKFKELRAKAEQHPIEATGRELRKLMAWVKSDDSDYVEGSAAR","proteome":"UP000001116","gene":"ilvC","go_terms":[{"identifier":"GO:0004455","name":"ketol-acid reductoisomerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009082","name":"branched-chain amino acid biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0050661","name":"NADP binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"23be5c984df3ce0fb023b39c00f37e3a52a70888","counters":{"domain_architectures":21735,"entries":20,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":2,"ssf":2,"pfam":2,"ncbifam":3,"hamap":1,"pirsf":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":21735}}}