{"metadata":{"accession":"A6U1P7","id":"TYSY_STAA2","source_organism":{"taxId":"359787","scientificName":"Staphylococcus aureus (strain JH1)","fullName":"Staphylococcus aureus (strain JH1)"},"name":"Thymidylate synthase","description":["Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis"],"length":318,"sequence":"MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYNGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV","proteome":null,"gene":"thyA","go_terms":[{"identifier":"GO:0004799","name":"thymidylate synthase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006231","name":"dTMP biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016741","name":"transferase activity, transferring one-carbon groups","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6571d43d0db3476d3b47929b03c39208d2a83a8a","counters":{"domain_architectures":27171,"entries":15,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"cdd":1,"ncbifam":2,"hamap":1,"panther":1,"prosite":1,"prints":1,"interpro":5},"proteome":0,"taxonomy":1,"similar_proteins":27171}}}