{"metadata":{"accession":"A5HUP6","id":"GSG7_ANOST","source_organism":{"taxId":"30069","scientificName":"Anopheles stephensi","fullName":"Anopheles stephensi (Indo-Pakistan malaria mosquito)"},"name":"gSG7 salivary protein","description":["Salivary protein with anticoagulant activity (PubMed:17456441). Inhibits activation of host kallikrein-kinin system by preventing the reciprocal activation of coagulation factor XII (F12) and prekallikrein (KLKB1), and subsequent release of bradykinin (PubMed:17456441). Inhibits host factor XII and high molecular weight kininogen (KNG1) binding to negatively charged surfaces (PubMed:17456441). Weakly inhibits the alternative pathway of complement system activation in the host (PubMed:33199367)"],"length":142,"sequence":"METKLVLALIACGVICLLQTTPTEATGKHVQQLMKVFRAIDFDFTKKAFYLHRAKYGVQNQLRNPLYLKAMSLPRSAKLSQPCLKKMIDEVNDLESTFYAGFSFNCHDHDQYSMDCLEAAEPTYLDGLKKLAASTEQCLVQK","proteome":"UP000076408","gene":null,"go_terms":null,"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"744d2eaf7533c831fd29777deb5e3599fdac4b0b","counters":{"domain_architectures":239,"entries":2,"isoforms":0,"proteomes":1,"sets":0,"structures":1,"taxa":1,"dbEntries":{"pfam":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":239}}}