{"metadata":{"accession":"A5HNY5","id":"A5HNY5_ANAPL","source_organism":{"taxId":"8839","scientificName":"Anas platyrhynchos","fullName":"Anas platyrhynchos (Mallard)"},"name":"Peroxisome proliferator-activated receptor gamma","description":["Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm"],"length":475,"sequence":"MVDTEMPFWPINFGISPVDLSAMDDHTHSFDIKPFTTVDFSSTSSPHYEDIPLARTDQTSIDYKYDIKLQDCQSAIKMEPPSPPYFSEKVQLYNKPHEESSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKRSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSGIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDQIKCKHVSPLQEQNKEVAIRIFQRCQFRSVEAVQEITEFAKNIPGFVNLDLNDQVTLLKYGVHEIIYTLLASLMNKDGVLISDGQGFMTREFLKSLRKPFCDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQIIKKTETDMSLHPLLQEIYKDLY","proteome":null,"gene":"PPARgamma","go_terms":[{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043565","name":"sequence-specific DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004879","name":"nuclear receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fa961cd3ee4597e14e9e7ddef340150e3dd14873","counters":{"domain_architectures":1081,"entries":28,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"smart":2,"profile":2,"ssf":2,"cathgene3d":2,"pfam":3,"cdd":2,"panther":1,"prosite":1,"prints":4,"interpro":9},"proteome":0,"taxonomy":1,"similar_proteins":1081}}}